abstract：:Cell-instructive hydrogels are attractive for skin repair and regeneration, serving as interactive matrices to promote cell adhesion, cell-driven remodeling and de novo deposition of extracellular matrix components. This paper describes the synthesis and photocrosslinking of cell-instructive pectin hydrogels using cel...

journal_title：Acta biomaterialia

authors： Pereira RF,Barrias CC,Bártolo PJ,Granja PL

更新日期：2018-01-15 00:00:00

abstract：:Peripheral nerve fibrosis and painful adhesions are common, recurring pathological sequelae following injury. In this study, vital human amnion (hAM), an increasingly interesting biomaterial for regenerative medicine, was investigated as a novel therapy. hAM was first analyzed in vitro regarding its anti-adhesive char...

journal_title：Acta biomaterialia

authors： Lemke A,Ferguson J,Gross K,Penzenstadler C,Bradl M,Mayer RL,Gerner C,Redl H,Wolbank S

更新日期：2018-01-15 00:00:00

abstract：:In this study, the Cu-doping mechanism of Biphasic Calcium Phosphate (BCP) was thoroughly investigated, as was its ionic release behavior, in order to elucidate cytotoxicity features of these bioceramics. BCP are composed of hydroxyapatite (Ca10(PO4)6(OH)2) and β-TCP (Ca3(PO4)2). The two phases present two different d...

journal_title：Acta biomaterialia

authors： Gomes S,Vichery C,Descamps S,Martinez H,Kaur A,Jacobs A,Nedelec JM,Renaudin G

更新日期：2018-01-01 00:00:00

abstract：:Stimuli responsive polyelectrolyte nanoparticles have been developed for chemo-photothermal destruction of breast cancer cells. This novel system, called layer by layer Lipo-graph (LBL Lipo-graph), is composed of alternate layers of graphene oxide (GO) and graphene oxide conjugated poly (l-lysine) (GO-PLL) deposited o...

journal_title：Acta biomaterialia

authors： Hashemi M,Omidi M,Muralidharan B,Tayebi L,Herpin MJ,Mohagheghi MA,Mohammadi J,Smyth HDC,Milner TE

更新日期：2018-01-01 00:00:00

abstract：:A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DO...

journal_title：Acta biomaterialia

authors： Zhou G,Xiao H,Li X,Huang Y,Song W,Song L,Chen M,Cheng D,Shuai X

更新日期：2017-12-01 00:00:00

abstract：:Bacterial interference using non-pathogenic Escherichia coli 83972 is a novel strategy for preventing catheter-associated urinary tract infection (CAUTI). Crucial to the success of this strategy is to establish a high coverage and stable biofilm of the non-pathogenic bacteria on the catheter surface. However, this non...

journal_title：Acta biomaterialia

authors： Zhu Z,Yu F,Chen H,Wang J,Lopez AI,Chen Q,Li S,Long Y,Darouiche RO,Hull RA,Zhang L,Cai C

更新日期：2017-12-01 00:00:00

abstract：:Polylactide (PLA) polymers containing five distinct lengths of fluorinated (from C3F7 to C13F27) and non-fluorinated (C6H13) end-groups were successfully synthesized by ring-opening polymerization of d,l-lactide. Fluorination was expected to increase the encapsulation efficiency of perfluorohexane (PFH). 150 nm nanoca...

journal_title：Acta biomaterialia

authors： Picheth G,Houvenagel S,Dejean C,Couture O,Alves de Freitas R,Moine L,Tsapis N

更新日期：2017-12-01 00:00:00

abstract：:Site-specific controlled release of exogenous angiogenic growth factors, such as recombinant human basic fibroblast growth factor (rhbFGF), has become a promising approach to improve peripheral vascular disease. Here, we have developed an implant composed of spiral magnesium (Mg) and a coating made using poly(lactic-c...

journal_title：Acta biomaterialia

authors： Bao H,Lv F,Liu T

更新日期：2017-12-01 00:00:00

abstract：:Hydrogels are appealing biomaterials for applications in regenerative medicine due to their tunable physical and bioactive properties. Meanwhile, therapeutic metal ions, such as magnesium ion (Mg2+), not only regulate the cellular behaviors but also stimulate local bone formation and healing. However, the effective de...

journal_title：Acta biomaterialia

authors： Zhang K,Lin S,Feng Q,Dong C,Yang Y,Li G,Bian L

更新日期：2017-12-01 00:00:00

abstract：:How to enhance tendon graft incorporation into bone tunnels for achieving satisfactory healing outcomes in patients with anterior cruciate ligament reconstruction (ACLR) is one of the most challenging clinical problems in orthopaedic sports medicine. Several studies have recently reported the beneficial effects of Mg ...

journal_title：Acta biomaterialia

authors： Wang J,Xu J,Song B,Chow DH,Shu-Hang Yung P,Qin L

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints. The standard of care, vascularized bone grafts, is limited by donor site morbidity and restricted availability. The aim of this study was to generate and test engineered, axially vascularized SVF cells-based bone substitutes...

journal_title：Acta biomaterialia

authors： Ismail T,Osinga R,Todorov A Jr,Haumer A,Tchang LA,Epple C,Allafi N,Menzi N,Largo RD,Kaempfen A,Martin I,Schaefer DJ,Scherberich A

更新日期：2017-11-01 00:00:00

abstract：:Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(d,l-lactide) domains was devel...

journal_title：Acta biomaterialia

authors： Kascholke C,Hendrikx S,Flath T,Kuzmenka D,Dörfler HM,Schumann D,Gressenbuch M,Schulze FP,Schulz-Siegmund M,Hacker MC

更新日期：2017-11-01 00:00:00

abstract：:Two commercial formulations of apatitic calcium phosphate cements (CPCs), Graftys® Quickset (QS) and Graftys® HBS (HBS), similar in composition but with different initial setting time (7 and 15min, respectively), were combined to ovine whole blood. Surprisingly, although a very cohesive paste was obtained after a few ...

journal_title：Acta biomaterialia

authors： Mellier C,Lefèvre FX,Fayon F,Montouillout V,Despas C,Le Ferrec M,Boukhechba F,Walcarius A,Janvier P,Dutilleul M,Gauthier O,Bouler JM,Bujoli B

更新日期：2017-10-15 00:00:00

abstract：:β-Cyclodextrin can form inclusion complex with a series of guest molecules including phenyl moieties, and has gained considerable popularity in the study of supramolecular nanostructure. In this study, a biodegradable nanocomplex (HA(CD)-4Phe4 nanocomplex) was developed from β-cyclodextrin grafted hyaluronic acid (HA)...

journal_title：Acta biomaterialia

authors： Ji Y,Shan S,He M,Chu CC

更新日期：2017-10-15 00:00:00

abstract：:Hydrogels have been recognized as crucial biomaterials in the field of tissue engineering, regenerative medicine, and drug delivery applications due to their specific characteristics. These biomaterials benefit from retaining a large amount of water, effective mass transfer, similarity to natural tissues and the abili...

journal_title：Acta biomaterialia

authors： Vedadghavami A,Minooei F,Mohammadi MH,Khetani S,Rezaei Kolahchi A,Mashayekhan S,Sanati-Nezhad A

更新日期：2017-10-15 00:00:00

abstract：:Postoperative adhesion is a serious complication that can further lead to morbidity and/or mortality. Polymer anti-adhesion barrier material provides an effective precaution to reduce the probability of postoperative adhesion. Clinical application requires these materials to be easily handled, biocompatible, biodegrad...

journal_title：Acta biomaterialia

authors： Yang Y,Liu X,Li Y,Wang Y,Bao C,Chen Y,Lin Q,Zhu L

更新日期：2017-10-15 00:00:00

abstract：:Gene therapies have great potential in regenerative medicine; however, clinical translation has been inhibited by low stability and limited transfection efficiencies. Herein, we incorporate collagen-mimetic peptide (CMP)-linked polyplexes in collagen scaffolds to increase DNA stability by up to 400% and enable tailora...

journal_title：Acta biomaterialia

authors： Urello MA,Kiick KL,Sullivan MO

更新日期：2017-10-15 00:00:00

abstract：:Bioactive ions released from bioceramics play important roles in bone regeneration; however, it is unclear how each ionic composition in complex bioceramics exerts its specific effect on bone regeneration. The aim of this study is to elucidate the functional effects of Sr and Si ions in bioceramics on the regeneration...

journal_title：Acta biomaterialia

authors： Mao L,Xia L,Chang J,Liu J,Jiang L,Wu C,Fang B

更新日期：2017-10-01 00:00:00

abstract：:The high brittleness and low strength of bioactive ceramics have severely restricted their application in bone repair despite the fact that they have been regarded as one of the most promising biomaterials. In the last few years, low-dimensional nanomaterials (LDNs), including carbon nanotubes, graphene and boron nitr...

journal_title：Acta biomaterialia

authors： Gao C,Feng P,Peng S,Shuai C

更新日期：2017-10-01 00:00:00

abstract：:Scaffold-free harvest of microtissue with a defined structure has received a great deal of interest in cell-based assay and regenerative medicine. In this study, we developed thermally expandable hydrogels with spatially controlled cell adhesive patterns for rapid harvest of geometrically controlled microtissue. We pa...

journal_title：Acta biomaterialia

authors： Lee YB,Kim SJ,Kim EM,Byun H,Chang HK,Park J,Choi YS,Shin H

更新日期：2017-10-01 00:00:00

abstract：:The rheology of ultrasoft materials like the human brain is highly sensitive to regional and temporal variations and to the type of loading. While recent experiments have shaped our understanding of the time-independent, hyperelastic response of human brain tissue, its time-dependent behavior under various loading con...

journal_title：Acta biomaterialia

authors： Budday S,Sommer G,Haybaeck J,Steinmann P,Holzapfel GA,Kuhl E

更新日期：2017-09-15 00:00:00

abstract：:Because of the increasing incidence of coronary artery disease, the importance of cardiovascular stents has continuously increased as a treatment of this disease. Biodegradable scaffolds fabricated from polymers and metals have emerged as promising materials for vascular stents because of their biodegradability. Altho...

journal_title：Acta biomaterialia

authors： Im SH,Jung Y,Kim SH

更新日期：2017-09-15 00:00:00

abstract：:We report on new types of chitosan-based nanogels via an ortho ester-based linkage, used as drug carriers for efficient chemotherapy. First, we synthesized a novel diacrylamide containing ortho ester (OEAM) as an acid-labile cross-linker. Subsequently, methacrylated succinyl-chitosan (MASCS) was prepared and polymeriz...

journal_title：Acta biomaterialia

authors： Yang G,Wang X,Fu S,Tang R,Wang J

更新日期：2017-09-15 00:00:00

abstract：:Electrospun scaffolds provide a promising approach for tissue engineering as they mimic the physical properties of extracellular matrix. Previous studies have demonstrated that electrospun scaffolds with porous features on the surface of single fibers, enhanced cellular attachment and proliferation. Yet, little is kno...

journal_title：Acta biomaterialia

authors： Chen H,Huang X,Zhang M,Damanik F,Baker MB,Leferink A,Yuan H,Truckenmüller R,van Blitterswijk C,Moroni L

更新日期：2017-09-01 00:00:00

abstract：:The boundary layers coating articular cartilage in synovial joints constitute unique biomaterials, providing lubricity at levels unmatched by any human-made materials. The underlying molecular mechanism of this lubricity, essential to joint function, is not well understood. Here we study the interactions between surfa...

journal_title：Acta biomaterialia

authors： Zhu L,Seror J,Day AJ,Kampf N,Klein J

更新日期：2017-09-01 00:00:00

abstract：:For next-generation regenerative medicine and cancer therapy applications, the development of multifunctional biodegradable biomaterials with good antibacterial activity, biocompatibility and gene delivery capability is showing increased interests. As a natural cationic polypeptide, poly(ε-l-lysine) (EPL) has been as ...

journal_title：Acta biomaterialia

authors： Zhou L,Xi Y,Yu M,Wang M,Guo Y,Li P,Ma PX,Lei B

更新日期：2017-08-01 00:00:00

abstract：:Although the use of biomedical devices in hospital-based care is inevitable, unfortunately, it is also one of the leading causes of the nosocomial infections, and thus demands development of novel antimicrobial materials for medical device fabrication. In the current study, a multi-defense mechanism against Gram-posit...

journal_title：Acta biomaterialia

authors： Pant J,Gao J,Goudie MJ,Hopkins SP,Locklin J,Handa H

更新日期：2017-08-01 00:00:00

abstract：:Breast cancer has become the second leading cause of cancer-related mortality in female wherein more than 90% of breast cancer-related death results from cancer metastasis to distant organs at advanced stage. The purpose of this study is to develop biodegradable nanoparticles composed of natural polypeptides and calci...

journal_title：Acta biomaterialia

authors： Wang TW,Yeh CW,Kuan CH,Wang LW,Chen LH,Wu HC,Sun JS

更新日期：2017-08-01 00:00:00

abstract：:The objective of this study is to design the manner of ephrinB2 immobilized onto polyacrylamide (PAAm) hydrogels with varied elasticity and evaluate the effect of hydrogels elasticity and the immobilized manner of ephrinB2 on the Runx2 expression of human mesenchymal stem cells (hMSC). The PAAm hydrogels were prepared...

journal_title：Acta biomaterialia

authors： Toda H,Yamamoto M,Uyama H,Tabata Y

更新日期：2017-08-01 00:00:00

abstract：:The physical and chemical properties of a biomaterial integrate with soluble cues in the cell microenvironment to direct cell fate and function. Predictable biomaterial-based control of integrated cell responses has been investigated with two-dimensional (2D) screening platforms, but integrated responses in 3D have la...

journal_title：Acta biomaterialia

authors： Usprech J,Romero DA,Amon CH,Simmons CA

更新日期：2017-08-01 00:00:00

abstract：:The development of an in situ formed pH-responsive theranostic nanocomposite for anticancer drug delivery and computed tomography (CT) imaging was reported. β-cyclodextrin-{poly(lactide)-poly(2-(dimethylamino) ethyl methacrylate)-poly[oligo(2-ethyl-2-oxazoline)methacrylate]}21 [β-CD-(PLA-PDMAEMA-PEtOxMA)21] unimolecul...

journal_title：Acta biomaterialia

authors： Lin W,Yao N,Qian L,Zhang X,Chen Q,Wang J,Zhang L

更新日期：2017-08-01 00:00:00

abstract：:Biological materials are the result of years of evolution and possess a number of efficient features and structures. Researchers have investigated the possibility of designing biomedical structures that take advantage of these structural features. Insect shells, such as beetle shells, are among the most promising type...

journal_title：Acta biomaterialia

authors： Lee HT,Kim HJ,Kim CS,Gomi K,Taya M,Nomura S,Ahn SH

更新日期：2017-07-15 00:00:00

abstract：:Understanding the composition of the adsorbed protein layer on a biomaterial surface is of an extreme importance as it directs the primary biological response. Direct detection using labeled proteins and indirect detection based on enzymatic assays or changes to mass, refractive index or density of a surface have been...

journal_title：Acta biomaterialia

authors： Sarem M,Vonwil D,Lüdeke S,Shastri VP

更新日期：2017-07-15 00:00:00

abstract：:Avidin was covalently conjugated to the surface of calcium phosphate nanoparticles, coated with a thin silica shell and terminated by sulfhydryl groups (diameter of the solid core about 50nm), with a bifunctional crosslinker connecting the amino groups of avidin to the sulfhydryl group on the nanoparticle surface. Thi...

journal_title：Acta biomaterialia

authors： van der Meer SB,Knuschke T,Frede A,Schulze N,Westendorf AM,Epple M

更新日期：2017-07-15 00:00:00

abstract：:A chitosan oligosaccharide (CSO)-indomethacin (IDM) conjugate (CI) was synthesized to fabricate chemosensitizing nanoparticles (NPs) for tumor-targeted drug delivery. IDM was conjugated to a CSO backbone via amide bond formation, of which successful synthesis was confirmed by proton-nuclear magnetic resonance analyses...

journal_title：Acta biomaterialia

authors： Lee JY,Termsarasab U,Lee MY,Kim DH,Lee SY,Kim JS,Cho HJ,Kim DD

更新日期：2017-07-15 00:00:00

abstract：:This study investigated whether a novel alkali-based surface modification enhances in vitro mineralization as well as in vivo bone formation around titanium (Ti) implants in a femoral condyle model of 36 male Wister rats. All implant surfaces were grit-blasted and then received either acid-etching treatment, alkali-ba...

journal_title：Acta biomaterialia

authors： Camargo WA,Takemoto S,Hoekstra JW,Leeuwenburgh SCG,Jansen JA,van den Beucken JJJP,Alghamdi HS

更新日期：2017-07-15 00:00:00

abstract：:Tendon pathology is associated with damage. While tendon damage is likely initiated by mechanical loading, little is known about the specific etiology. Damage is defined as an irreversible change in the microstructure that alters the macroscopic mechanical parameters. In tendon, the link between mechanical loading and...

journal_title：Acta biomaterialia

authors： Lee AH,Szczesny SE,Santare MH,Elliott DM

更新日期：2017-07-15 00:00:00

abstract：:A challenge in using bioactive melt-derived glass in bone regeneration is to produce scaffolds with interconnected pores while maintaining the amorphous nature of the glass and its associated bioactivity. Here we introduce a method for creating porous melt-derived bioactive glass foam scaffolds with low silica content...

journal_title：Acta biomaterialia

authors： Nommeots-Nomm A,Labbaf S,Devlin A,Todd N,Geng H,Solanki AK,Tang HM,Perdika P,Pinna A,Ejeian F,Tsigkou O,Lee PD,Esfahani MHN,Mitchell CA,Jones JR

更新日期：2017-07-15 00:00:00

abstract：:This paper presents a strain-mediated phenomenological corrosion model, based on the discrete finite element modelling method which was developed for use with the ANSYS Implicit finite element code. The corrosion model was calibrated from experimental data and used to simulate the corrosion performance of a WE43 magne...

journal_title：Acta biomaterialia

authors： Galvin E,O'Brien D,Cummins C,Mac Donald BJ,Lally C

更新日期：2017-06-01 00:00:00

abstract：:Self-assembling peptides programed by sequence design to form predefined nanostructures are useful for a variety of biomedical applications. However, assemblies of classic ionic self-complementary peptides are unstable in neutral pH, while charged peptide hydrogels have low mechanical strength. Here, we report on the ...

journal_title：Acta biomaterialia

authors： Zhang H,Park J,Jiang Y,Woodrow KA

更新日期：2017-06-01 00:00:00